Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis
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چکیده
منابع مشابه
Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis.
Tumor metastasis is a complex multistep process by which cells from the primary tumor invade tissues, move through the vasculature, settle at distant sites and eventually grow to form secondary tumors. Altered tyrosine phosphorylation signals in cancer cells contribute to a number of aberrant characteristics involved in tumor invasion and metastasis. CUB domain-containing protein 1 (CDCP1) is a...
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We report the application of quantitative mass spectrometry to identify plasma membrane proteins differentially expressed in melanoma cells with high vs. low metastatic abilities. Using stable isotope labeling with amino acids in culture (SILAC) coupled with nanospray tandem mass spectrometry, we identified CUB-domain-containing protein 1 (CDCP1) as one such differentially expressed transmembra...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2011
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2011.02052.x